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Thermodynamics of protein folding and structure of the free energy landscape へ行く。
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** protein folding and structure of free energy landscape[#u25c88de]

Proteins natively take a specific structure (native structure) and thereby function in living-cells.~
The structure forming has been explained based on the energy landscape picture without frustration (&color(Red){funnel};-shaped landscape).~
We attempt to extend the energy landscape picture with weak &color(Red){frustration}; and examine the effect of the frustration.
#ref(IIS_Fig1.png);
**Publications [#i1f41256]
-K. Matsushita and M. Kikuchi "Flustration induced protein intrinsic disorder" [[Journal of Chemical Physics 138, 105101 (2013)>http://jcp.aip.org/resource/1/jcpsa6/v138/i10/p105101_s1]]
-K. Matsushita and M. Kikuchi "Flustration induced protein intrinsic disorder" [[Journal of Chemical Physics ''138'', 105101 (2013)>http://jcp.aip.org/resource/1/jcpsa6/v138/i10/p105101_s1]]
-K. Matsushita and M. Kikuchi "Short Polypeptide with Metastable Structures" [[Interdisciplinary Information Sciences ''19''(1) (2013) 29-34>https://www.jstage.jst.go.jp/article/iis/19/1/19_IIS190104/_article]]
**References [#e6ad01d8]
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--[[J. D. Bryngelson and P. G. Wolynes, Proc. Natl. Acad. Sci. USA 84, 7524 (1987)>http://www.pnas.org/content/84/21/7524]].
--[[J. D. Bryngelson and P. G. Wolynes, J. Phys. Chem. 93, 6902 (1989)>http://pubs.acs.org/doi/abs/10.1021/j100356a007]].
--[[M. Sasai and P. G. Wolynes, Phys. Rev. Lett. 65, 2740&#8211;2743 (1990)>http://prl.aps.org/abstract/PRL/v65/i21/p2740_1]]
--[[P. G. Wolynes, J. N. Onuchic and D. Thirumalai, Science 267, 1619 (1995) >http://www.sciencemag.org/content/267/5204/1619.refs]]
--[[S. Takada and P. G. Wolynes, Phys. Rev. E 55, 4562&#8211;4577 (1997) >http://pre.aps.org/abstract/PRE/v55/i4/p4562_1]]