Physics of Intrinsically Disordered Protein (IDP) のバックアップ(No.3)

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• Physics of Intrinsically Disordered Protein (IDP) へ行く。
  • 1 (2013-07-10 (水) 16:04:41)
  • 2 (2013-08-13 (火) 13:56:46)
  • 3 (2013-08-25 (日) 16:44:00)

Intrinsically Disordered Protein (IDP)

IDP is a protein which natively does not take any stable steric structures.

Functions of proteins in a cell originate from the steric structures of the proteins.
However IDP has a function, despite nature of IDP.
The mechanism of function of IDP is not well understood.
We theoretically investigate the mechanism of the function.

The following figure shows an example of dynamics of IDP in the molecular dynamics simulation.

Publications

• K. Matsushita and M. Kikuchi "Flustration induced protein intrinsic disorder" Journal of Chemical Physics 138, 105101 (2013)
• K. Matsushita and M. Kikuchi "Multicanonical simulation of coupled folding and binding of intrinsically disordered protein using an Ising-like protein model" Journal of Physics: Conference Series 454 012034(7) (2013)
  

References

• Wright and Dyson, Journal of Molecular Biology Volume 293, Issue 2, 22 October 1999, Pages 321-331