Physics of Intrinsically Disordered Protein (IDP) のバックアップソース(No.1)

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• Physics of Intrinsically Disordered Protein (IDP) へ行く。
  • 1 (2013-07-10 (水) 16:04:41)
  • 2 (2013-08-13 (火) 13:56:46)
  • 3 (2013-08-25 (日) 16:44:00)

** &color(Red){I};ntrinsically &color(Red){D};isordered &color(Red){P};rotein (IDP)[#jf6b534c]
&color(Red){IDP}; is a protein which natively does not take any steric structures.~
~
Functions of proteins in a cell originate from the steric structures of the proteins.~
However IDP plays a function, despite IDP's nature.~
The mechanism of IDP's function is not well understood.~
~
The following figure shows an example of dynamics of IDP in the molecular dynamics simulation.~
&ref("protein_motion.gif",,40%);

-K. Matsushita and M. Kikuchi "Flustration induced protein intrinsic disorder" [[Journal of Chemical Physics 138, 105101 (2013)>http://jcp.aip.org/resource/1/jcpsa6/v138/i10/p105101_s1]]
-Wright and Dyson, [[Journal of Molecular Biology Volume 293, Issue 2, 22 October 1999, Pages 321-331>http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WK7-45SR5DX-J&_user=9152734&_coverDate=10%2F22%2F1999&_rdoc=1&_fmt=high&_orig=search&_origin=search&_sort=d&_docanchor=&view=c&_acct=C000011799&_version=1&_urlVersion=0&_userid=9152734&md5=d92d8b61ce255e0045b3e95272cea0c6&searchtype=a]]